Dermatomyositis-like eruption associated with hydroxyurea therapy: a premalignant condition?
نویسندگان
چکیده
Hydroxyurea (HU) is an anticancer agent that inhibits DNA synthesis through its action on the enzyme ribonucleotide reductase.1 It is used in chronic myeloproliferative diseases such as polycythemia vera, chronic myeloid leukemia, and essential thrombocytosis, although it has also been prescribed to patients with refractory psoriasis.2 We present the case of a 76-year-old woman diagnosed with idiopathic myelofibrosis and on treatment with
منابع مشابه
Hydroxyurea-associated dermatomyositis-like eruption demonstrating abnormal epidermal p53 expression: a potential premalignant manifestation of chronic hydroxyurea and UV radiation exposure.
BACKGROUND Chronic hydroxyurea therapy is associated with numerous cutaneous adverse effects. While hydroxyurea-associated nonmelanoma skin cancers are known to be associated with significant morbidity and occasional mortality, to date, dermatomyositis-like eruption has been considered a benign entity, other than its ability to mimic true dermatomyositis leading to inappropriate immunosuppressi...
متن کامل[Multiple, painful, treatment-resistant leg ulcers associated with dermatomyositis-like lesions over the interphalangeal joints induced by hydroxyurea].
The onset of a dermatomyositis-like rash and persistent skin ulcers during long-term treatment with hydroxyurea is a very rare event that has not been fully described in the literature. The fact that these lesions have a typical clinical presentation and course, and that complete resolution can only be achieved by immediate withdrawal of the drug, means that dermatologists should be aware of th...
متن کاملSuccessful treatment of hydroxyurea-associated panniculitis and vasculitis with low-dose methotrexate
INTRODUCTION Hydroxyurea is a standard treatment for myeloproliferative disorders because of its cytoreductive effects on all bone marrow cell lines. As a hydroxylated derivative of urea, it inhibits DNA synthesis by inactivating ribonucleotide diphosphate reductase. Hydroxyurea is generally well tolerated. However, a variety of cutaneous side effects including leg ulcers, dermatomyositis, and ...
متن کاملBreast Cancer Associated with Dermatomyositis
Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy with characteristic skin lesions. Case series have shown an association between dermatomyositis and malignancy. Malignancy has been found in 15-25% of the adult patients with dermatomyositis. A 50-year-old new case of breast cancer, was admitted with muscle weakness and inability to walk. Physical examination revealed fever, perior...
متن کاملHydroxyurea-induced amyopathic dermatomyositis presenting with heliotrope erythema.
Hydroxyurea (HU) is a chemotherapeutic agent used for the treatment of myeloproliferative disorders such as chronic myeloid leukemia, polycythemia vera, and essential thrombocytosis. We describe a 69-year-old man who had essential thrombocytosis and developed amyopathic dermatomyositis after long-term HU therapy. He presented with Gottron papules and heliotrope erythema. The former has been des...
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عنوان ژورنال:
- Actas dermo-sifiliograficas
دوره 105 9 شماره
صفحات -
تاریخ انتشار 2014